Officials say the blaze broke out in a four-story apartment building on Tompkins Avenue, 367 in Bedford-Stavesant after 11 p.m.
Firefighters found a 74-year-old woman unconscious on the third floor after putting out a fire with three alarms.
She was pronounced dead at the scene.
One firefighter received non-life-threatening injuries.
The cause of the fire is being investigated.
This is the latest news. This story will be updated as more information becomes available.
Copyright © 2022 WABC-TV. All rights reserved.